Repolarization Heterogeneity: Beyond the QT Interval
نویسندگان
چکیده
منابع مشابه
Repolarization Heterogeneity: Beyond the QT Interval
R esearch over the past 2 decades has suggested that significant differences exist in the action potentials of endocardial, epicardial, and mid-myocardial (M) cells that comprise the ventricular myocardium. Relative differences in the time course of repolarization of these 3 cell types, referred to as transmural dispersion of repolarization (TDR), is largely responsible for the inscription of t...
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A 14-year-old girl was admitted with generalized tonic-clonic convulsions for 2min along with tongue biting. Her family reported previous recurrent attacks of muscle cramps and carpo-pedal spasms of four months’ duration prior to admission but they had never previously sought medical help. The patient had a good appetite and no diarrhea, with no prior history of cardiovascular disease or sympto...
متن کامل[Corrected QT interval and corrected QT interval dispersion is worthwhile when interpreted with other repolarization measurements].
We read the article entitled ‘‘The effect of esmolol on corrected-QT interval, corrected-QT interval dispersion changes seen during anesthesia induction in hypertensive patients taking an angiotensin-converting enzyme inhibitor’’ by Ceker et al. with interest.1 The authors investigated the effects of esmolol on the hemodynamic, correctedQT (QTc) interval and corrected-QT interval dispersion (QT...
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Ventricular repolarization (VR) is a crucial step in cardiac electrical activity because it corresponds to a recovery period setting the stage for the next heart contraction. Small perturbations of the VR process can predispose an individual to lethal arrhythmias. In this review, I aim to provide an overview of the methods developed to analyse static and dynamic aspects of the VR process when r...
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Regulatory subunit KCNE3 (E3) interacts with KCNQ1 (Q1) in epithelia, regulating its activation kinetics and augmenting current density. Since E3 is expressed weakly in the heart, we hypothesized that ectopic expression of E3 in cardiac myocytes might abbreviate action potential duration (APD) by interacting with Q1 and augmenting the delayed rectifier current (I(K)). Thus, we transiently coexp...
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ژورنال
عنوان ژورنال: Journal of the American Heart Association
سال: 2016
ISSN: 2047-9980,2047-9980
DOI: 10.1161/jaha.116.003607